Tuning iron homeostasis to treat chronic disease
Higher iron levels in our body can drive many ages of disease like neurodegeneration, cancer, and metabolic syndrome. We're using our GRETA platform to map how cells respond to oxidative stress brought on by iron. Our potential therapies are built to restore iron homeostasis in disease.
Our pipeline
Sarcoma
Target Identified
Hit Discovered
Lead Discovered
Lead Optimization
Our first-in-class GPX4 inhibitor is leading to extremely significant tumor growth inhibition in multiple mouse models of cancer. LEARN MORE
KEAP1-mutant Lung Cancer
Target Identified
Hit Discovered
Lead Discovered
Lead Optimization
We've discovered a novel NRF2 pathway inhibitor with significant activity in KEAP1-mutant lung adenocarcinomas. LEARN MORE
Chronic Kidney Disease
Target Identified
Hit Discovered
Lead Discovered
We've discovered a targeted Ferroptosis blocker that prevents renal injury in mice. LEARN MORE
Neurodegeneration
Target Identified
Hit Discovered
We've discovered a targeted Ferroptosis blocker that prevents neuronal cell death in microglia associated with Parkinson's. LEARN MORE